Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency.
As part of the Nucleotide Excision Repair (NER) Musical Instrument Amplifiers process, the endonuclease XPG is involved in repair of helix-distorting DNA lesions, but the protein has also been implicated in several other DNA repair systems, complicating genotype-phenotype relationship in XPG patients.Defects in XPG can cause either the cancer-prone